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Nitrogen mustard compounds

Nitrogen mustards are cytotoxic organic compounds with the chloroethylamine functional group, which consists of the following structure: Cl(CH2)2NR2, where R can be any organic group. They are nitrogen analogs of mustard gas.
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Keyword Search:
46 – 60 of 173 results
46

Medchemexpress LLC MS4077 | 2230077-10-6 | 99.7% | 1134.73 | 10 MG
SDP

MS4077 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 37 nM for binding affinity to ALK. It is for research use only and not sold to patients.

  • Effectively inhibits cancer cell proliferation.
  • Concentration-dependently inhibits proliferation of SU-DHL-1 cells with an IC50 of 46 ± 4 nM.
  • Potently reduces ALK fusion protein levels and inhibits ALK auto-phosphorylation and downstream STAT3 phosphorylation in SU-DHL-1 and NCI-H2228 cells.
  • Reduces NPM-ALK protein levels with a DC50 of 3 ± 1 nM in SU-DHL-1 cells after 16-hour treatment.
  • Achieves over 90% inhibition of both ALK Y1507 and STAT3 Y705 phosphorylation at 100 nM concentration.
  • Reduces EML4-ALK protein levels with a DC50 of 34 ± 9 nM in NCI-H2228 cells after 16-hour treatment, with over 90% reduction at 100 nM.

ENCOMPASS_PREFERRED
47

Medchemexpress LLC ZL0580 | 2377151-10-3 | 99.4% | 532.53 | 100 MG
SDP

ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. It induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.

  • Induces epigenetic suppression of HIV
  • Selectively binds to BD1 domain of BRD4
  • Inhibits Tat transactivation and transcription elongation
  • Induces repressive chromatin structure at the HIV promoter
  • Suppresses HIV in primary CD4+ T cells
  • Exhibits low toxicity in cell viability assays

ENCOMPASS_PREFERRED
48

Medchemexpress LLC HN37 | 1821222-10-9 | 99.5% | 340.39 g/mol | C20H21FN2O2 | 5 MG
SDP

HN37 is a small-molecule research compound that functions as a potent activator of the KCNQ2 potassium channel. It contains an alkyne moiety suitable for click-chemistry derivatization and is intended for in vitro pharmacology and chemical biology applications.

  • Potent KCNQ2 activation with EC50 of 37 nM.
  • Alkyne functional group suitable for copper-catalyzed azide-alkyne cycloaddition.
  • High reported purity for reproducible assay performance.
  • Soluble in DMSO at 50 mg/mL for preparation of concentrated stocks.
  • Available in multiple milligram quantities for research use.

ENCOMPASS_PREFERRED
49

Medchemexpress LLC ML-184 10mg | 794572-10-4 | 470.63 g·mol⁻¹ | C25H34N4O3S | 10 MG
SDP

ML-184 is a selective GPR55 agonist research compound supplied for in vitro and preclinical pharmacology studies. It is provided as a solid and as ready-to-use DMSO solutions, and is characterized by molecular formula C25H34N4O3S and molecular weight 470.63 g·mol⁻¹.

  • Selective GPR55 agonist (EC50 ≈ 250 nM)
  • Suitable for in vitro and preclinical research applications
  • Available as a 10 mg solid and as 10 mM solution in DMSO
  • High purity (99.57%) as provided by manufacturer
  • Store powder at -20°C for long-term stability; store solutions at -80°C for extended storage

ENCOMPASS_PREFERRED
50

Medchemexpress LLC Vu0467485 | 1451994-10-7 | 99.3% | 25 MG
SDP

VU0467485 (AZ13713945) is a potent, selective, orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator supplied for research use.

  • Potent and selective M4 positive allosteric modulator
  • Orally bioavailable in preclinical studies
  • High purity suitable for analytical and screening applications
  • Available in small milligram-scale packages for research
  • Characterized molecular weight and formula for reproducibility

ENCOMPASS_PREFERRED
51

Medchemexpress LLC RV01 | 1016897-10-1 | 98.1% | 263.29 g/mol | C17H13NO2 | 10MG
SDP

RV01 is a resveratrol analogue used as a research tool to probe ALDH2-related pathways and oxidative stress. It inhibits DNA damage, reduces ethanol-induced ALDH2 mRNA expression, scavenges hydroxyl radicals, and decreases iNOS expression, indicating anti-neuroinflammatory activity. Supplied as a powder for biochemical and cell-based research applications.

  • Inhibits DNA damage and reduces ALDH2 mRNA expression.
  • Scavenges hydroxyl radicals, indicating antioxidant activity.
  • Decreases iNOS expression and exhibits anti-neuroinflammatory effects.
  • Provided as a research-grade powder suitable for biochemical studies.
  • High purity for reliable experimental results.

ENCOMPASS_PREFERRED
52

Medchemexpress LLC Rv01 | 1016897-10-1 | 98.1% | 263.29 g/mol | C17H13NO2 | 50MG
SDP

RV01 is a resveratrol analogue that inhibits aldehyde dehydrogenase (ALDH) activity and reduces ethanol-induced ALDH2 mRNA expression. Supplied as a solid research compound for in vitro biochemical and cellular studies, it has documented solubility in DMSO and defined storage/stability conditions.

ENCOMPASS_PREFERRED
53

Medchemexpress LLC 5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide | 1451994-10-7 | 99.3% | 50 MG
SDP

VU0467485 (AZ13713945) is a potent, selective, orally bioavailable positive allosteric modulator of the muscarinic acetylcholine receptor M4, provided as a research reagent for receptor pharmacology and preclinical studies.

  • Potent and selective M4 positive allosteric modulator.
  • Orally bioavailable properties support in vivo evaluation.
  • High purity suitable for pharmacological assays.
  • Available in multiple pack sizes, including 50 mg.
  • Commonly used for studies of M4 signaling and antipsychotic-like activity in preclinical models.

ENCOMPASS_PREFERRED
54

Medchemexpress LLC CDC25B-IN-1 | 2374831-10-2 | 98.1% | 321.37 g/mol | C20H19NO3 | 50MG
SDP

CDC25B-IN-1 is a small-molecule research inhibitor of the cell division cycle 25B (CDC25B) phosphatase. It has a reported Ki of approximately 8.5 μM, reduces cell proliferation and colony formation, and increases the proportion of cells in the G2/M phase. The compound is supplied at high reported purity and is available in multiple pack sizes, including mg quantities and as a DMSO solution suitable for biochemical and cell-based assays.

  • Potent inhibitor of CDC25B phosphatase with reported Ki ≈ 8.5 μM.
  • Inhibits cell proliferation and colony formation in cellular assays.
  • Causes accumulation of cells in the G2/M phase.
  • Supplied with high reported purity for research use.
  • Available in multiple pack sizes and as a DMSO solution for convenience.

ENCOMPASS_PREFERRED
55

eMolecules​ ChemScene / 4-(Cyclopropylsulfonimidoyl)aniline / 100mg / 761283903 / CS-0184344 / 0.000 / 1523618-10-1 / MFCD27987215 / 196.270 / C9H12N2OS

ChemScene / 4-(Cyclopropylsulfonimidoyl)aniline / 100mg / 761283903 / CS-0184344 / 0.000 / 1523618-10-1 / MFCD27987215 / 196.270 / C9H12N2OS

ENCOMPASS_PREFERRED
56

eMolecules​ AstaTech / 2-([11-BIPHENYL]-2-YL)ACETONITRILE / 1g / 493153604 / 34109 / 98.000 / 19853-10-2 / MFCD00060294 / 193.249 / C14H11N

AstaTech / 2-([11-BIPHENYL]-2-YL)ACETONITRILE / 1g / 493153604 / 34109 / 98.000 / 19853-10-2 / MFCD00060294 / 193.249 / C14H11N

ENCOMPASS_PREFERRED
57

Medchemexpress LLC Camonsertib | 2417489-10-0 | MFCD34578462 | 100.0% | C21H26N6O3 | 10MG
SDP

Camonsertib is an orally active, selective ATR kinase inhibitor developed for oncology research and clinical investigation. It exhibits low-nanomolar biochemical potency against ATR, reported selectivity versus related kinases, and has shown antitumor activity in preclinical and early clinical studies. The compound is supplied as a high-purity solid for research use only.

  • Potent ATR inhibition with low-nanomolar biochemical potency.
  • High selectivity versus related kinases, limiting off-target effects.
  • Demonstrated antitumor activity in preclinical and early clinical evaluations.
  • Provided as a high-purity solid suitable for laboratory research.
  • Available in small research-scale quantities for experimental studies.

ENCOMPASS_PREFERRED
58

Medchemexpress LLC Gamcemetinib | 1887069-10-4 | 99.1% | C22H20ClN5O3S | 10MG
SDP

Gamcemetinib is a covalent, irreversible inhibitor of MAP kinase-activated protein kinase-2 (MK2) used as a research compound for in vitro and preclinical studies. It is characterized by submicromolar activity in biochemical and cell-based assays and is supplied as a solid or as a DMSO solution for laboratory use.

  • Potent, covalent MK2 inhibitor with low-nanomolar to submicromolar activity.
  • High purity suitable for research use (≈99.1%).
  • Available as multiple solid quantities and as a 10 mM solution in DMSO for convenience.
  • Soluble in DMSO; enhanced solubility with warming and sonication.
  • Defined storage recommendations for powder and solution to preserve stability.

ENCOMPASS_PREFERRED
59

STA PHARMACEUTICAL US LLC 3-(9-fluorenylmethoxycarbonylamido)-tricyclo[3.3.1.1(3.7)]decane-1-carboxylic acid | 5 g | CAS 875211-10-2 | InChIKey RXRDRSUDCSEVRK-UHFFFAOYSA-N

3-(9-fluorenylmethoxycarbonylamido)-tricyclo[3.3.1.1(3.7)]decane-1-carboxylic acid is a Amino Acid reagent (Subcategory: Alkane AA) sold by WuXi TIDES. Offered in 5 g. Store at 4 °C. SDS available for reference.

Specifications
- CAS: 875211-10-2
- MDL: No data
- InChIKey: RXRDRSUDCSEVRK-UHFFFAOYSA-N
- Molecular Weight: 417.505
- Molecular Formula: C26H27NO4
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)adamantane-1-carboxylic acid
- SMILES: OC(C12CC3CC(C2)CC(C1)(NC(OCC4C5=CC=CC=C5C6=CC=CC=C46)=O)C3)=O

ENCOMPASS
60

Chemscene ChemScene | 4,7-Dibromoisoquinoline | 250MG | CS-0139734 | 0.97 | 223671-10-1| MFCD13191776 | 286.95
SDP

ChemScene | 4,7-Dibromoisoquinoline | 250MG | CS-0139734 | 0.97 | 223671-10-1| MFCD13191776 | 286.95

ENCOMPASS_PREFERRED